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Researchers Develop DNA Compounds that May Help Treat Lupus

May 28, 2009 By MedNews Leave a Comment

A research team led by a University of Iowa investigator has generated DNA-like compounds that effectively inhibit the cells responsible for systemic lupus erythematosus — the most common and serious form of lupus. There currently is no cure for this chronic autoimmune condition that damages the skin, joints and internal organs and affects an estimated one million Americans.

The team, which included researchers at Boston University School of Medicine, demonstrated the anti-inflammatory effects of class R inhibitory oligonucleotides in laboratory experiments. The findings, which could eventually lead to new treatments, appear May 28 in BioMed Central’s open access journal Arthritis Research and Therapy.

“The increased potency of class R inhibitory oligonucleotides for certain cells involved in lupus flare-ups could help patients by providing specific inhibition, yet allowing them to generate a protective immune response when needed,” said the study’s lead author, Petar Lenert, M.D., Ph.D., assistant professor of internal medicine at the University of Iowa Roy J. and Lucille A. Carver College of Medicine.

During periodic flare-ups in people with lupus, the immune system overreacts and mistakenly attacks cells and tissues throughout the body, resulting in a range of symptoms including inflammation, pain and a characteristic “butterfly rash” across the cheeks.

Using human cell lines and isolated mouse cells, Lenert and his colleagues showed that the DNA-like compounds were able to selectively reduce the activity of two types of immune cells called autoreactive B cells and dendritic cells. When given to mice with lupus, the compounds delayed death and reduced kidney damage, proving their effectiveness.

“With further testing, we hope that class R inhibitory oligonucleotides may become another weapon in the fight against lupus,” Lenert said.

Lupus prevalence varies by country and ethnicity. It is much more common in women than men; nine out of 10 people with lupus are female. Lupus also is three times more common in African-American women than in Caucasian women and is more prevalent in women of Latino, Asian and Native American descent.

The study received grants from the National Institutes of Health and the Alliance for Lupus Research.

Source: University of Iowa Health Sciences, May 27, 2009

Filed Under: General Health Tagged With: genetics, lupus

World Health Organization Reports ~14,000 Cases of Swine Flu Worldwide

May 28, 2009 By MedNews Leave a Comment

Novel influenza A (H1N1) is a new flu virus of swine origin that was first detected in April, 2009. The virus is infecting people and is spreading from person-to-person, sparking a growing outbreak of illness in the United States. An increasing number of cases are being reported internationally as well.

It’s thought that novel influenza A (H1N1) flu spreads in the same way that regular seasonal influenza viruses spread; mainly through the coughs and sneezes of people who are sick with the virus.

It’s uncertain at this time how severe this novel H1N1 outbreak will be in terms of illness and death compared with other influenza viruses. Because this is a new virus, most people will not have immunity to it, and illness may be more severe and widespread as a result. In addition, currently there is no vaccine to protect against this novel H1N1 virus. CDC anticipates that there will be more cases, more hospitalizations and more deaths associated with this new virus in the coming days and weeks.

Country Cumulative total
  
Newly confirmed since the last reporting period
  Cases Deaths Cases Deaths
Argentina 19 0 14 0
Australia 39 0 20 0
Austria 1 0 0 0
Bahrain 1 0 1 0
Belgium 7 0 0 0
Brazil 9 0 0 0
Canada 921 1 0 0
Chile 86 0 12 0
China 22 0 2 0
Colombia 16 0 0 0
Costa Rica 33 1 0 0
Cuba 4 0 0 0
Denmark 1 0 0 0
Ecuador 28 0 4 0
El Salvador 11 0 5 0
Finland 2 0 0 0
France 16 0 0 0
Germany 17 0 0 0
Greece 1 0 0 0
Guatemala  5 0 1 0
Honduras 1 0 0 0
Iceland 1 0 0 0
India 1 0 0 0
Ireland 1 0 0 0
Israel 9 0 1 0
Italy 23 0 4 0
Japan 360 0 10 0
Korea, Republic of 21 0 0 0
Kuwait 18 0 0 0
Malaysia 2 0 0 0
Mexico 4541 83 367 3
Netherlands 3 0 0 0
New Zealand 9 0 0 0
Norway 4 0 0 0
Panama 76 0 0 0
Peru 27 0 0 0
Philippines 2 0 0 0
Poland 3 0 0 0
Portugal 1 0 0 0
Russia 2 0 0 0
Singapore 1 0 1 0
Spain 138 0 2 0
Sweden 3 0 0 0
Switzerland 3 0 0 0
Thailand 2 0 0 0
Turkey 2 0 0 0
United Kingdom 137 0 0 0
United States of America 6764 10 0 0
Grand
Total
13398 95 444 3

Chinese Taipei has reported 4 confirmed cases of influenza A (H1N1) with 0 deaths. Cases from Chinese Taipei are included in the cumulative totals provided in the table above.

Cumulative and new figures are subject to revision

Source: WHO, May 27, 2009 (international cases table); CDC (background information)

Filed Under: Infectious Diseases

Genetic Link Between Heart Disease and Gum Disease

May 28, 2009 By MedNews Leave a Comment

BBC News reports that a genetic link between gum disease and heart attacks has been found by researchers in Germany.
Periodontitis (gum disease) is known to be associated with heart disease but how exactly they are linked is unknown.

Now the University of Kiel team has found a common gene mutation in people with periodontitis and heart attack patients, a conference heard.

Source: BBC, May 25, 2009
news.bbc.co.uk/1/hi/health/8063512.stm

Filed Under: General Health Tagged With: genetics, gum disease, heart disease

Drinking While Pregnant Still a Problem

May 28, 2009 By MedNews Leave a Comment

Exposure to alcohol is a known cause of birth defects, yet the number of women who drink alcohol while pregnant is not decreasing, according to a 15 year-study by the Centers for Disease Control and Prevention. Approximately 1 in 8 women drank any amount of alcohol while pregnant, the study says.

The drinking patterns persisted despite repeated warnings from surgeons general about the dangers of drinking alcohol while pregnant. The surgeons general have told pregnant women, and women who may become pregnant to abstain from alcohol consumption in order to eliminate the chance of giving birth to a baby with alcohol related birth defects.

The CDC analysis, as well as a study also published today by the U.S. Substance Abuse and Mental Health Services Administration shows that far too many women use substances (especially alcohol) during their pregnancies.

The CDC study, “Alcohol Use Among Women of Childbearing Age, United States, 1991-2005,” is in the CDC′s Morbidity and Mortality Weekly Report.

The CDC study also found that 1 of every 50 pregnant women engaged in binge drinking each year during the 15 years.

“Exposure to alcohol can cause lifelong physical and mental disabilities that are preventable by avoiding alcoholic drinks while pregnant,” said Edwin Trevathan, director of the CDC′s National Center on Birth Defects and Developmental Disabilities. “All women should know that there is no known safe amount of alcohol to drink or safe time to drink it during pregnancy. We encourage all women to pay attention to the surgeon general warnings.”

The study found that pregnant women most likely to report any alcohol use were 35-44 years of age (17.7 percent), college graduates (14.4 percent), employed (13.7 percent), and unmarried (13.4 percent). Pregnant women who binge drink were more likely to be employed and unmarried than were pregnant women who did not binge drink. This study did not examine the reasons why women are still drinking while pregnant.

Any alcohol use was defined as at least one drink of any alcoholic beverage in the past 30 days. Binge drinking was defined as having five or more drinks on at least one occasion in the past 30 days.

“By screening and advising women about the risks of drinking while pregnant, health care providers can play a key role in reducing rates of fetal alcohol syndrome,” said Clark Denny, a CDC epidemiologist and primary author of the study. “This study revealed that there is still a great need for health care professionals to routinely ask all women who are pregnant or at risk of being pregnant about their alcohol consumption.”

The study examined data from 533,506 women aged 18-44 years, of whom 22,027 reported being pregnant at the time of the interview. The data were obtained from the Behavioral Risk Factor Surveillance System (BRFSS). The BRFSS is a state-based system of health surveys that collects information on health risk behaviors, preventive health practices, and health care access primarily related to chronic disease and injury. Data are collected monthly in all 50 states, the District of Columbia, Puerto Rico, the U.S. Virgin Islands, and Guam.

source: CDC, 5/21/09

Filed Under: Alcohol, Pediatrics & Parenting

Prilosec, Nexium and Prevacid Tied to Higher Risk of Pneumonia

May 27, 2009 By MedNews 1 Comment

A new study has found that hospital patients who are given proton pump inhibitors–drugs that help prevent acid reflux–are at higher risk for pneumonia than those who are not given these medications.

The drugs — including Nexium, Prilosec and Prevacid — are often recommended for intensive-care patients to prevent stress ulcers, and in recent years they have been given to many other hospital patients, in large part because they are widely perceived to be safe. Experts estimate that 40 percent to 70 percent of inpatients now receive acid-suppressive drugs during a hospital stay, with about half receiving them for the first time.

Source: New York Times, May 26, 2009
nytimes.com/2009/05/27/health/27drugs.html

Filed Under: General Health

Test Well Water Once a Year for Children’s Health

May 27, 2009 By MedNews Leave a Comment

Private well water should be tested yearly, and in some cases more often, according to new guidance offered by the American Academy of Pediatrics (AAP).

Researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, took a lead role in working with the AAP to develop these recommendations and draft a new AAP policy statement about the things parents should do if their children drink well water. The recommendations call for annual well testing, especially for nitrate and microorganisms such as coliform bacteria, which can indicate that sewage has contaminated the well.

The recommendations point out circumstances when additional testing should occur, including testing when there is a new infant in the house or if the well is subjected to structural damage.

“Children are especially vulnerable to waterborne illnesses that may come from contaminated wells,” said Walter J. Rogan, M.D., an epidemiologist at NIEHS and lead author on the policy statement and technical report that appears in the June issue of Pediatrics. The new policy statement, “Drinking Water from Private Wells and Risks to Children,” offers recommendations for inspection, testing and remediation of wells providing drinking water for children.

“With few exceptions, well owners are responsible for their own wells,” said Rogan. Private wells are not subject to federal regulations and are only minimally regulated by states. With proper care, well water is safe; however, wells can become contaminated by chemicals or pathogenic organisms.

Nitrate, which comes from sewage or fertilizer, is the most common contaminant in wells. The presence of nitrates can be a problem particularly for infants under three months who can not metabolize nitrate. Water with a nitrate concentration of more than 1.0 milligrams per liter should not be used to prepare infant formula or given to a child younger than one year. The policy statement suggests using bottled water for infants when nitrate contamination is detected, or when the source of drinking water is not known.

The policy statement and accompanying technical report point out that water contamination is inherently local, and that families with wells need to keep in contact with state and local health experts to determine what should be tested in their community. For example, some parts of the country may have arsenic, radon, salt intrusion or agricultural runoff that may get into the water supply.

“As people move out of urban and suburban areas into areas that are not reached by municipal water supplies, it is more important than ever that people know who to contact in their local health department to get information about local groundwater conditions,” said N. Beth Ragan of NIEHS, who served as consultant on these reports. A compilation of state by state telephone and Web-based resources of local experts is included in the technical report. Approximately one-sixth of U.S. households now get their drinking water from private wells.

NIEHS Director Linda Birnbaum, Ph.D., says she is pleased that NIEHS researchers took the lead in writing this statement, and continue their longstanding liaisons with the American Academy of Pediatrics to develop state-of-the-science technical reports that can have a direct impact on public health.

“This statement will be extremely useful to many audiences — especially pediatricians,” Birnbaum said. “Pediatricians needed a one-stop shopping document that they can share with parents who have concerns about their children�s sources of drinking water.”

Source: NIH, May 26, 2009

Filed Under: General Health, Pediatrics & Parenting

Pool Chemical Injuries Threaten Thousands

May 25, 2009 By MedNews Leave a Comment

Pool chemical injuries account for as many as 5,200 emergency room visits each year. A new study by the Centers for Disease Control and Prevention shows that these injuries are preventable, and during 2007 almost half of those injuries occurred at a residence.

According to the study, published in CDC′s Morbidity and Mortality Weekly Report (MMWR), persons can be injured by inhaling fumes when they open pool chemical containers, attempting to pre-dissolve pool chemicals, or handling them improperly. Persons can also be injured when chemicals splash into the eyes. These preventable injuries typically occur during the summer swimming season, from Memorial Day to Labor Day, and can occur in or out of the pool.

In addition to pool chemical injuries, thousands of people each year suffer from recreational water illnesses. The study was released ahead of CDC′s National Recreational Water Illness Prevention Week, May 18-24. The week aims to raise awareness about healthy swimming behaviors, including ways to prevent recreational water illnesses and injuries. Recreational water illnesses are illnesses spread by swallowing, inhaling vapors, or having contact with contaminated water in swimming pools, water parks, spas, interactive fountains, lakes, rivers, or oceans.

“Pool chemicals make the water we swim in safer by protecting us from germs, but these same chemicals can also cause injuries if they are not properly handled,” said Michele Hlavsa, the study′s lead author and epidemiologist at CDC.

Public pool operators and residential pool owners can protect themselves and swimmers by always securing pool chemicals, reading product names and manufacturer′s directions before each use, using appropriate protective gear including safety glasses and gloves, and never mixing chlorine products with each other, with acid, or with any other substance.

The study looked at 36 pool chemical-associated health events reported to the New York state Department of Health for recreational water venues, such as pools, water parks, and interactive water fountains, during 1983-2006.

Swimming is the second most popular sports activity in the United States, with approximately 339 million swimming visits to recreational water venues.

The best way to prevent recreational water illnesses is to keep germs out of the pool in the first place. Everyone can help create healthy swimming experiences by not swimming when ill with diarrhea, not swallowing pool water, taking kids on bathroom breaks and practicing good hygiene.

Source: CDC, May 23, 2009

Filed Under: General Health, Pediatrics & Parenting

Samsca Approved by FDA to Treat Hyponatremia

May 23, 2009 By MedNews Leave a Comment

The U.S. Food and Drug Administration has approved Samsca tablets (tolvaptan) to treat hyponatremia, an abnormally low concentration of sodium in the blood.

“With the approval of Samsca, physicians will have an additional tool to treat hyponatremia,” said Norman Stockbridge, M.D., director of the Division of Cardiovascular and Renal Products in the FDA’s Center for Drug Evaluation and Research.

Samsca is approved to treat hyponatremia associated with congestive heart failure, liver cirrhosis, and the syndrome of inappropriate antidiuretic hormone secretion.

When sodium levels drop in the fluid outside of cells throughout the body, water moves into cells to balance the sodium levels and causes the cells to swell. Swelling of the brain cells is thought to cause many of the symptoms of hyponatremia. Those symptoms may include fatigue, weakness, headache, nausea, confusion or decreased consciousness, and convulsions. Severe hyponatremia, which has not been studied with Samsca, can lead to coma and death.

Samsca helps raise sodium levels in the blood by removing extra body water in the urine. Patients using the drug in clinical trials had a greater degree of increase in sodium levels in the blood compared with patients taking a pill containing no active drug (placebo).

Samsca is being approved with a boxed warning to alert health care professionals and patients that the drug should be started only in a hospital where blood sodium can be monitored closely. Too rapid a rise in sodium can cause a serious condition called osmotic demyelination syndrome (ODS). ODS can lead to coma or death and can also cause symptoms such as trouble speaking, trouble swallowing, drowsiness, confusion, mood changes, seizures and trouble controlling body movement with muscle weakness in the arms and legs.

Although no cases of ODS were seen in clinical trials of Samsca, ODS is a known risk and it is essential that physicians be aware of it and avoid rapid rises in sodium. Additionally, the FDA is requiring a Risk Evaluation and Mitigation Strategy that requires a patient Medication Guide be given out when the drug is dispensed. The Medication Guide will provide information about the drug’s benefits and risks.

The most common adverse reactions with use of Samsca reported by patients in clinical trials include thirst, dry mouth, weakness, constipation, making large amounts of urine, urinating often, and increased blood sugar levels.

Samsca is marketed by Otsuka Pharmaceuticals Co. Ltd., Tokyo, Japan.

Source: FDA, May 22, 2009

Filed Under: Drug Approvals, FDA News & Alerts

Vitamin D3 Deficiency

May 22, 2009 By Pate53 Leave a Comment

Health columnist Pamela Egan addresses the importance of Vitamin D3, and goes into thorough detail about the potential adverse effects on one’s health that can result from a Vitamin D3 deficiency.

Filed Under: General Health

Experimental Therapy Uses Body’s Immune System to Increase Cure Rate in Neuroblastoma Patients

May 16, 2009 By MedNews 1 Comment

A multicenter research team has announced encouraging results for an experimental therapy using elements of the body’s immune system to improve cure rates for children with neuroblastoma, a challenging cancer of the nervous system.

John M. Maris, M.D., chief of Oncology at The Children’s Hospital of Philadelphia, co-authored the phase 3 clinical trial, which was led by Alice Yu, M.D., Ph.D., of the University of California, San Diego. Maris chairs the committee supervising the trial for the Children’s Oncology Group, a cooperative organization that pools resources from leading medical centers to study and devise new treatments for pediatric cancers.

Neuroblastoma, a cancer of the peripheral nervous system, usually appears as a solid tumor in the chest or abdomen. Neuroblastoma accounts for 7 percent of all childhood cancers, but due to its often aggressive nature, causes 15 percent of all childhood cancer deaths.

Yu will present the neuroblastoma study results on June 2 at the annual meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Fla. In advance of the meeting, ASCO published the findings online on May 14.

Maris explained that immunotherapy for cancer involves triggering the body’s immune system to attack cancer cells. Monoclonal antibodies are molecules customized to target particular cancers, while cytokines are naturally occurring signaling proteins that regulate the body’s immune responses.

In the current study, Children’s Oncology Group researchers studied 226 children with high-risk neuroblastoma. Half received the immunotherapy, while half received standard therapy (chemotherapy and stem cell transplantation). The patients who received the immunotherapy were 20 percent more likely than those in the standard therapy group to live disease-free two years after treatment. “This 20 percent improvement in preventing relapse led to a greater cure rate—the first substantial increase in cure rate for neuroblastoma for more than a decade,” said Maris.

The researchers halted the trial earlier than expected after early results showed the benefits of immunotherapy. “This experimental immunotherapy is poised to become part of the new standard of care for children with the aggressive form of neuroblastoma,” said Maris.

Maris added that the supply of the antibodies and cytokines used in the trial was limited, and that pediatric oncologists were seeking biotechnology companies to move the biological agents into commercial production to make the treatment readily available to children with neuroblastoma.

The Children’s Hospital of Philadelphia has one of the nation’s largest clinical and research programs in neuroblastoma. In 2008, Maris led a study that was the first to identify the gene location at which neuroblastoma originates. His laboratory continues to investigate how genes contribute to the disease, using that knowledge to devise new treatments.

Maris served as an oncologist for Alex Scott, the child with neuroblastoma who started a lemonade stand in 2000 to raise money for programs in childhood cancer. Now operated through the Scott family, the Alex’s Lemonade Stand Foundation supports ongoing research by members of the Children’s Oncology Group.

Source: American Society of Clinical Oncology, May 14, 2009

Filed Under: Cancer, Pediatrics & Parenting

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