University of California, San Francisco researchers have found that men with a history of infertility have a markedly increased risk of subsequently developing testicular cancer. The purpose of the study was to assess testicular cancer in infertile men usingna cohort study methodology.
More than 51,000 couples, drawn from 15 California infertility centers during the period 1965 and 1995, were evaluated for infertility. Male subjects’ medical records were linked to the California Cancer Registry, the cumulative Surveillance Epidemiology and End Results Registry (SEER) for the State of California. Cancers preceding infertility were excluded from analysis, and the incidence of testicular cancer in this cohort was compared to age-matched men from the general population.
The study found that men from infertile couples were 60% more likely to develop testicular cancer than other men (standardized incidence ratio 1.695% confidence interval 1.2 to 2.2). This risk was relatively constant across all age strata.