In a study funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, Saint Louis University’s Center for Vaccine Development is investigating whether the standard vaccine used in foreign countries against tuberculosis offers better protection as a shot, drink or combination of both.

“The fight against tuberculosis is important because a third of the world is thought to be infected and there are significant problems with drug-resistant TB organisms,” said Daniel Hoft, M.D., Ph.D., principal investigator and director of the division of immunobiology at Saint Louis University School of Medicine.

The “standard” tuberculosis vaccine, bacillus Calmette-Guérin (BCG), is given to infants in foreign countries, and is not currently recommended for use in the U.S.

“Experts believe it provides some protection against TB disease, particularly in children where severe manifestations of TB are averted,” Hoft said. “However, despite widespread use of BCG, TB remains a major cause of death worldwide. The main purpose of this study is to find out if BCG can be used in a more effective way.

“We hope to learn whether a BCG vaccine drink or a combination of a drink and an injection could increase immune responses against tuberculosis lung infection and affect the progression of the disease as it spreads throughout the body.”

The study also will look at whether it is better to give one or two doses of the BCG vaccine.

A total of 70 healthy volunteers who are 18 to 40 years old are needed for the research. The study will last about two years and requires up to 21 scheduled visits. Each visit takes between 30 minutes and three hours, depending upon the procedures being performed. Study participants will be compensated for their time and travel after each completed visit.

Tuberculosis is a deadly disease that strikes developing nations hardest. Each year, nearly 8 million new cases of TB develop, and 2 million persons die from the infectious disease.

Source: Saint Louis University Medical Center, June 12, 2009

Fighting infectious disease, the very heart of public health and the genesis of contemporary nursing, is about more than hand washing and immunizations. It’s about screening and early detection, identifying risk and protective factors, and educating clinicians, facilities and the public. But it all begins with research

Infectious disease rates, stable since the 1918 influenza pandemic, have been on the rise since the mid-1980s. The battle against these illnesses—from HIV/AIDS to MRSA and from STDs to resurgent tuberculosis (TB), and others—has been escalating, and long before the recent emergence of the H1N1 influenza virus earlier this year.

For Johns Hopkins University School of Nursing (JHUSON) nurse researchers, the communities around the corner and around the world are their infectious disease laboratories.

JHUSON faculty research, for example, is shedding light on curbing sexually transmitted infections and their physical and emotional repercussions on college campuses. It also is exploring best practices to curtail the spread of resurgent diseases like tuberculosis and reducing the impact of treatment resistant infections like MRSA both within and beyond the hospital setting.

The community-based inquiry not only is yielding new knowledge but also, when coupled with its translation into clinical education and practice, is helping to save lives today and to be better prepared to save them in an uncertain future.

Infection Detective at Work in High-Risk Environments: JHUSON researcher, Assistant Professor and self-professed “infection control preventionist” Jason Farley, PhD, MPH, ARNP, is working to give nurse colleagues and other health care professionals the research-based tools they need to identify, prevent, and destroy drug-resistant infections in hospitals and in communities from Maryland to South Africa.

Growing rates of drug-resistant infections like tuberculosis and methicillin-resistant staphylococcus aureus (MRSA), coupled with recent H1N1 pandemic concerns, make his work most timely. His MRSA-related research not only has documented its evolution from a hospital problem into a community and public health concern, but also has given health providers.

Farley’s work is as much about transmitting knowledge as it is about curbing infection transmission. In new work supported by the JHU’s Center on Global Health, he is evaluating current tuberculosis infection control practices and strategies in TB hospitals throughout South Africa. With highly drug-resistant TB adding to the significant toll taken by HIV/AIDS in that country, the need to improve infection control is marked. Yet, Farley has found considerable inattention to such issues as segregated care for TB-infected patients, lack of evaluation and testing of health care workers for the disease, and limited use of respirators to combat the spread of this airborne disease.

Farley notes, “Infection control needs to be paramount in our thoughts about patient safety and also in how we avoid infection in health care workers.” His work in South Africa seeks to determine if a trained infection control nurse can help reduce or eliminate these and other gaps in infection control. From a public health perspective, Farley says, “No one knows about infection control better than nurses. It’s where our profession’s evidence-based roots began; nurses will continue to be on the front lines of infection prevention and public education tomorrow.”

Breaking through the Sound of Silence: When the Infection is Sexual—Most sexually transmitted diseases (STDs) can be readily treated and cured; all can be prevented. Yet, in the U.S. alone, as many as 19 million new cases of a sexually transmitted disease (STD) are diagnosed each year, almost half of which are among sexually active teens and young adults.

Many are symptom-free, don’t even know they have an STD, and, as a result, don’t get treated. Others whose STD symptoms are evident, may lack access to care or may be too ashamed, afraid or upset to discuss the illness, much less get treatment for it. In either case, continuing infection and ongoing transmission are likely. Whether well-known STDs like gonorrhea, syphilis and HIV/AIDS or less familiar ones like chlamydia and herpes, the physical repercussions of untreated STDs can be significant, ranging from pelvic disease to infertility, cervical cancer, even death, with attendant health care costs and lost productivity.

The emotional toll can be equally or even more devastating, particularly since so many affected and infected are between the ages of 15 and 24. JHUSON Assistant Professor, Hayley D. Mark, PhD, MPH, RN doesn’t think that’s good for the public health and has been working to change the situation through research.

Drawn to the field of STD research because it “affects the human condition as a whole – health, psychology and social environment,” she noted that certain STDs tend to be passed around within specific closed communities, such as a college campus, the nightclub scene or the correctional facility.

While it is well know that screening reduces the likelihood of transmitting HIV and bacterial STDs, Mark wondered whether wide-scale, voluntary screening also could help reduce the incidence of the transmission of genital herpes, HSV-2, a viral, often silent STD. that puts people at greater risk for HIV infection.

She began her inquiry on a college campus, assessing how to motivate student participation in STD screening and the performance characteristics of the HSV test in college students , reported in the Journal of American College Health and Sexually Transmitted Disease, respectively. Results suggested that to be successful, information about the availability of screening for HSV-2 should be neutral in tone and informative, transmitted broadly by a trusted source such as a student health center. Further, Mark’s finding that a diagnosis of HVS-2 often causes significant emotional and social difficulty (social break-ups, depression, and anxiety) led her to recommend the value of both immediate and follow-up counseling to address both the medical and psychological aspects of infection.

Mark believes nurses are ideally poised to break through the silence that so often surrounds STDs. She notes, “Because we are trained to help people feel comfortable in an uncomfortable medical environment, we can help open the door to STD prevention as well as to screening and treatment. Part of what we do is help people talk about difficult health topics by providing a nonjudgmental environment in which knowledge can be shared. It’s a great model of how nurses work to promote the public health.”

Source: Johns Hopkins University School of Nursing, June 12, 2009